Qp code: Reg. Number:.........
Second Professional MBBS Degree Examination
(MODEL QUESTION PAPER)
PHARMACOLOGY- Paper I
Time: 2 hrs Max marks: 40
• Answer all questions.
• Draw diagrams wherever necessary
Essays: (2x6=12)
1. Enumerate four groups of antihypertensives with one example for each. Mention four
drugs safe for use in pregnancy. Describe the pharmacological action, adverse
effects and drug interaction of any one antihypertensive (2+2+ 2= 6)
2. Read the clinical problem and answer the following questions: Ramesh, 28 years
was administered an injection of adrenaline with lignocaine at base of his thumb for
nail extraction. Later he developed severe gangrene of thumb:
• Why has gangrene developed and how could this have been avoided.
• Mention the mechanism and pharmacological actions of adrenaline and
lignocaine
• List two other surface anaesthetics and mention their adverse effects
• Mention the cardiac use of lignocaine with dose and rationale. (1+2+2+1=6)
Short notes: (5x3=15)
3. Sucinylcholine
4. Teratogenicity
5. Ketamine
6. Chlorpromazine
7. Cardiogenic shock
Answer briefly: (5x1=5)
8. Rationale for use of sumatriptan in acute attack of migraine
9. Two uses and two adverse effects of lithium
10. Appropriate drug and justification of the use of Diazepam / Alparazolam in
depressed person with anxiety.
11. Mechanism of action of neostigmine
12. Tachyphylaxis. List one example
Name two drugs for: (8x1=8)
13. Grandmal epilepsy
14. Drugs administered sublingually
15. Cerebroselective anticholinesterases
16. 5HT3 antagonists
17. Antidepressants effective in chronic pain
18. Fibrinolytic agents
19. Drugs for hypotension
20. Diuretics used in cerebral edema
