SECOND PROFESSIONAL MBBS DEGREE
EXAMINATION
PHARMACOLOGY PAPER II
(NEW SCHEME)
Time: 2 hours Maximum marks: 40
Answer all
questions.
I. Name the following
a) The
laxative preferred in a patient with hepatic coma
b) Longest
acting penicillin
c) DOC for
VRSA
d) Site of
action of caspofungin
e) Route of
administration of Streptomycin
f) Insulin in
diabetic pregnant woman
g) A
cephalosporin causing Disulfiram like reaction
h) The
Tetracycline active against Mycobacterium leprae
i) The drug
used to treat antibiotic associated pseudomembranous colitis
j) The
antifungal preferred in fungal meningitis (1/2 x 10 = 5
marks)
II .Specify the important spectrum of
the following antimicrobial agents
a.
Ceftriaxone
b.
Azithromycin
c. Vancomycin
d. Linezolid
e. Rifampin (1x 5=5marks)
III. Write two important uses and two
contraindications of
1.
Ketoconazole
2.
Methotrexate
3.
Tetracycline
4.
Metronidazole (1x4= 4marks)
IV. Comment on the interaction
produced by the following drugs
1.
Propranolol and Glibenclamide
2.
Sulfamethoxazole and Trimethoprim
3.
Ciprofloxacin and theophylline
4. Dapsone
and pyrimethamine (1x4=4marks)
V. Read the case history and answer
the following questions
Ramesh 40
years, is an alcoholic and a smoker. He gives history of nausea, abdominal
pain,
heart burn,
loss of appetite and one episode of haematemesis. Endoscopy confirms peptic
ulceration
1) Prescribe
a drug for the above condition with dosage schedule
2) Write its
mechanism of action and adverse effects
3) What
advice on life style modification should be given to him?
4) List two
drugs from different groups which can cause peptic ulceration
(1½+1½ + 1+1=
5 marks)
VI. Classify oral Hypoglycemic drugs. Write the mechanism of
action, adverse effects and
drug
interactions of any one drug. Name two drugs which cause hyperglycemia
(2½ +1½ +1=
5marks)
VII. Write briefly on
a. Protease
inhibitors
b.
Cyclophosphamide
c. OCP
d. Newer
Insulins (3x4= 12
marks)
